Article
Genome-wide association analyses identify two susceptibility loci for pachychoroid disease central serous chorioretinopathy.
Communications biology - 1 Jan 2019
Hosoda Yoshikatsu, Miyake Masahiro, Schellevis Rosa L, Boon Camiel J F, Hoyng Carel B, Miki Akiko, Meguro Akira, Sakurada Yoichi, Yoneyama Seigo, Takasago Yukari, Hata Masayuki, Muraoka Yuki, Nakanishi Hideo, Oishi Akio, Ooto Sotaro, Tamura Hiroshi, Uji Akihito, Miyata Manabu, Takahashi Ayako, Ueda-Arakawa Naoko, Tajima Atsushi, Sato Takehiro, Mizuki Nobuhisa, Shiragami Chieko, Iida Tomohiro, Khor Chiea Chuen, Wong Tien Yin, Yamada Ryo, Honda Shigeru, de Jong Eiko K, Hollander Anneke I den, Matsuda Fumihiko, Yamashiro Kenji, Tsujikawa Akitaka
Abstract excerpt
The recently emerged pachychoroid concept has changed the understanding of age-related macular degeneration (AMD), which is a major cause of blindness; recent studies attributed AMD in part to pachychoroid disease central serous chorioretinopathy (CSC), suggesting the importance of elucidating the CSC pathogenesis. Our large genome-wide association study followed by validation studies in three independent...
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