Article
Kindlin-2 Association with Rho GDP-Dissociation Inhibitor α Suppresses Rac1 Activation and Podocyte Injury.
Journal of the American Society of Nephrology : JASN - 1 Dec 2017
Sun Ying, Guo Chen, Ma Ping, Lai Yumei, Yang Fan, Cai Jun, Cheng Zhehao, Zhang Kuo, Liu Zhongzhen, Tian Yeteng, Sheng Yue, Tian Ruijun, Deng Yi, Xiao Guozhi, Wu Chuanyue
Abstract excerpt
Alteration of podocyte behavior is critically involved in the development and progression of many forms of human glomerular diseases. The molecular mechanisms that control podocyte behavior, however, are not well understood. Here, we investigated the role of Kindlin-2, a component of cell-matrix adhesions, in podocyte behavior in vivo Ablation of Kindlin-2 in podocytes resulted in alteration of actin cytoskeletal...
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