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Article

Morphological and proliferative abnormalities in renal mesangial cells lacking RhoGDI.

Cellular signalling - 1 Dec 2009

Bielek Heike, Anselmo Anthony, Dermardirossian Celine

Abstract excerpt

The regulation of Rho GTPase activities and expression is critical in the development and function of the kidney. Rho GTPase activities and cytosol-membrane cycling are regulated by Rho GDP Dissociation Inhibitor (RhoGDI), and RhoGDI knockout mice develop defects in kidney structure and function that lead to death due to renal failure. It is therefore important to understand the changes in RhoGDI-regulated Rho...

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Identifiers

PMID: 19765647
DOI: 10.1016/j.cellsig.2009.09.008
PMCID: PMC2903048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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