Article
Role of Rho-GTPases and their regulatory proteins in glomerular podocyte function
18 Jun 2013
Abstract excerpt
Podocytes play a critical role in maintaining glomerular permselectivity. It has been long recognized that their intricate actin-based structures are tightly associated with their normal function; however, the precise mechanisms by which podocytes form and maintain their complex structure had been poorly understood until the intensive investigations on podocyte biology began in 1998, triggered by the breakthrough...
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