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Article

Suppression of Wnt Signaling and Osteogenic Changes in Vascular Smooth Muscle Cells by Eicosapentaenoic Acid.

Nutrients - 10 Aug 2017

Saito Yukihiro, Nakamura Kazufumi, Miura Daiji, Yunoki Kei, Miyoshi Toru, Yoshida Masashi, Kawakita Norifumi, Kimura Tomonari, Kondo Megumi, Sarashina Toshihiro, Akagi Satoshi, Watanabe Atsuyuki, Nishii Nobuhiro, Morita Hiroshi, Ito Hiroshi

Abstract excerpt

Vascular medial calcification is often observed in patients with arteriosclerosis. It is also associated with systolic hypertension, wide pulse pressure, and fluctuation of blood pressure, which results in cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular calcification in previous animal experiments. We investigated the inhibitory effects of EPA on Wnt signaling, which is one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28796175
DOI: 10.3390/nu9080858
PMCID: PMC5579651

Genes

AXIN2
BMP4
RUNX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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