Article
PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites.
Circulation. Cardiovascular genetics - 1 Aug 2017
Kent Shia T, Rosenson Robert S, Avery Christy L, Chen Yii-Der I, Correa Adolfo, Cummings Steven R, Cupples L Adrienne, Cushman Mary, Evans Daniel S, Gudnason Vilmundur, Harris Tamara B, Howard George, Irvin Marguerite R, Judd Suzanne E, Jukema J Wouter, Lange Leslie, Levitan Emily B, Li Xiaohui, Liu Yongmei, Post Wendy S, Postmus Iris, Psaty Bruce M, Rotter Jerome I, Safford Monika M, Sitlani Colleen M, Smith Albert V, Stewart James D, Trompet Stella, Sun Fangui, Vasan Ramachandran S, Woolley J Michael, Whitsel Eric A, Wiggins Kerri L, Wilson James G, Muntner Paul
Abstract excerpt
BACKGROUND: PCSK9 loss-of-function (LOF) variants allow for the examination of the effects of lifetime reduced low-density lipoprotein cholesterol (LDL-C) on cardiovascular events. We examined the association of PCSK9 LOF variants with LDL-C and incident coronary heart disease and stroke through a meta-analysis of data from 8 observational cohorts and 1 randomized trial of statin therapy. METHODS AND RESULTS:...
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