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Article

Associations Between Soluble LDLR and Lipoproteins in a White Cohort and the Effect of PCSK9 Loss-of-Function.

The Journal of clinical endocrinology and metabolism - 1 Sept 2018

Mayne Janice, Ooi Teik Chye, Tepliakova Lioudmila, Seebun Deeptee, Walker Krystal, Mohottalage Dhanuddara, Ning Zhibin, Abujrad Hussein, Mbikay Majambu, Wassef Hanny, Chrétien Michel, Figeys Daniel

Abstract excerpt

Context: Elevated circulating cholesterol-rich low-density lipoprotein (LDL) particles increase coronary artery disease risk. Cell-surface hepatic LDL receptors (LDLRs) clear 70% of these particles from circulation. The ectodomain of LDLR is shed into circulation, preventing it from removing LDL particles. The role that LDLR ectodomain shedding plays as a regulatory mechanism is unknown. Objective: We describe...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cholesterol, LDL

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Source

Identifiers

PMID: 29982529
DOI: 10.1210/jc.2018-00777

Genes

LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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