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Article

Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations.

Lipids in health and disease - 10 May 2013

Mayne Janice, Ooi Teik Chye, Raymond Angela, Cousins Marion, Bernier Lise, Dewpura Thilina, Sirois Francine, Mbikay Majambu, Davignon Jean, Chrétien Michel

Abstract excerpt

OBJECTIVES: Variants of the secreted glycoprotein, proprotein convertase subtilisin/kexin 9 (PCSK9), associate with both hypo- and hyper-cholesterolemic phenotypes. Herein, we carried out full exonic sequencing of PCSK9 documenting the frequency of single and multiple PCSK9 variations and their effects on serum lipoprotein and PCSK9 levels in Caucasian Canadians. METHODS: The 12 exons of PCSK9 were sequenced in...

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Identifiers

PMID: 23663650
DOI: 10.1186/1476-511X-12-70
PMCID: PMC3661383

Genes

PCSK9

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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