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Article

Validation and Implementation of a Custom Next-Generation Sequencing Clinical Assay for Hematologic Malignancies.

The Journal of molecular diagnostics : JMD - 1 Jul 2016

Kluk Michael J, Lindsley R Coleman, Aster Jon C, Lindeman Neal I, Szeto David, Hall Dimity, Kuo Frank C

Abstract excerpt

Targeted next-generation sequencing panels to identify genetic alterations in cancers are increasingly becoming an integral part of clinical practice. We report here the design, validation, and implementation of a comprehensive 95-gene next-generation sequencing panel targeted for hematologic malignancies that we named rapid heme panel. Rapid heme panel is amplicon based and covers hotspot regions of oncogenes...

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Identifiers

PMID: 27339098
DOI: 10.1016/j.jmoldx.2016.02.003
PMCID: PMC5707186

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