Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL.

doi:10.1007/s00428-016-2025-7

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Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL.

Virchows Archiv : an international journal of pathology - 1 Jan 2017

Deans Zandra C, Costa Jose Luis, Cree Ian, Dequeker Els, Edsjö Anders, Henderson Shirley, Hummel Michael, Ligtenberg Marjolijn Jl, Loddo Marco, Machado Jose Carlos, Marchetti Antonio, Marquis Katherine, Mason Joanne, Normanno Nicola, Rouleau Etienne, Schuuring Ed, Snelson Keeda-Marie, Thunnissen Erik, Tops Bastiaan, Williams Gareth, van Krieken Han, Hall Jacqueline A

Abstract excerpt

The clinical demand for mutation detection within multiple genes from a single tumour sample requires molecular diagnostic laboratories to develop rapid, high-throughput, highly sensitive, accurate and parallel testing within tight budget constraints. To meet this demand, many laboratories employ next-generation sequencing (NGS) based on small amplicons. Building on existing publications and general guidance for...

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PMID: 27678269
DOI: 10.1007/s00428-016-2025-7
PMCID: PMC5243883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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