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Article

Unveiling cellular mechanisms underlying MYZAP related dilated cardiomyopathy using patient specific hiPSC cardiomyocytes.

Scientific reports - 21 Apr 2026

Zakzook Fatma, Cherian Reeja Maria, Prajapati Chandra, Pekkanen-Mattila Mari, Ahola Antti, Koskenvuo Juha, Heliö Krista, Heliö Tiina, Aalto-Setälä Katriina

Abstract excerpt

Dilated cardiomyopathy (DCM) remains a leading cause of heart failure lacking effective treatments. Despite clinical advances, its pathogenic mechanisms are diverse and unclear. Recent attention has increasingly focused on the intercalated disc (ID), a specialized structure essential for mechanical and electrical coupling between cardiomyocytes and implicated in hereditary cardiomyopathies. MYZAP, an ID protein...

Topics

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Cardiomyopathy, Dilated
DSP gene
SRF gene
TNNT2 gene
Induced Pluripotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Myocytes, Cardiac

Source

Open in PubMed Open full text

Identifiers

PMID: 42014428
DOI: 10.1038/s41598-026-48921-5
PMCID: PMC13273059

Genes

MYZAP
DSP
CDH2
NPPB
SRF
TJP1
TNNT2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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