Article
Arrhythmogenic cardiomyopathy: pathogenesis, pro-arrhythmic remodelling, and novel approaches for risk stratification and therapy.
Cardiovascular research - 15 Jul 2020
van der Voorn Stephanie M, Te Riele Anneline S J M, Basso Cristina, Calkins Hugh, Remme Carol Ann, van Veen Toon A B
Abstract excerpt
Arrhythmogenic cardiomyopathy (ACM) is a life-threatening cardiac disease caused by mutations in genes predominantly encoding for desmosomal proteins that lead to alterations in the molecular composition of the intercalated disc. ACM is characterized by progressive replacement of cardiomyocytes by fibrofatty tissue, ventricular dilatation, cardiac dysfunction, and heart failure but mostly dominated by the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.