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Article

Assembly of the Cardiac Intercalated Disk during Pre- and Postnatal Development of the Human Heart

14 Apr 2014

Abstract excerpt

BACKGROUND: In cardiac muscle, the intercalated disk (ID) at the longitudinal cell-edges of cardiomyocytes provides as a macromolecular infrastructure that integrates mechanical and electrical coupling within the heart. Pathophysiological disturbance in composition of this complex is well known to trigger cardiac arrhythmias and pump failure. The mechanisms underlying assembly of this important cellular domain in...

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PMID: 24733085
DOI: 10.1371/journal.pone.0094722

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