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Article

PANoptosis is a prominent feature of desmoplakin cardiomyopathy

1 Jan 2022

Abstract excerpt

Introduction: Arrhythmogenic cardiomyopathy (ACM) is hereditary cardiomyopathy caused by pathogenic variants (mutations) in genes encoding the intercalated disc (ID), particularly desmosome proteins. ACM caused by mutations in the DSP gene encoding desmoplakin (DSP) is characterized by the prominence of cell death, myocardial fibrosis, and inflammation, and is referred to as desmoplakin cardiomyopathy. Aim: The...

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PMID: 36818425
DOI: 10.20517/jca.2022.34

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