Article

Co-transcriptional splicing facilitates transcription of gigantic genes

2024-04-02

Abstract excerpt

Although introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kilobases (kb) to megabases (Mb). It remains unknown why gigantic introns exist and how cells overcome the challenges associated with their transcription and RNA processing....

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Literature Corpus work: 6396e584-a3fb-5263-bd4d-2774696aaca8
DOI: 10.1101/2024.04.02.587678

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