Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and analysis of deleterious human SNPs.

Journal of molecular biology - 10 Mar 2006

Yue Peng, Moult John

Abstract excerpt

We have developed two methods of identifying which non-synonomous single base changes have a deleterious effect on protein function in vivo. One method, described elsewhere, analyzes the effect of the resulting amino acid change on protein stability, utilizing structural information. The other method, introduced here, makes use of the conservation and type of residues observed at a base change position within a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Databases, Protein
Share to DNA Mutational Analysis
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Mice, Knockout

Share to Proteins

Share to Sensitivity and Specificity

Source

Identifiers

PMID: 16412461
DOI: 10.1016/j.jmb.2005.12.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and analysis of deleterious human SNPs.PMID 16412461Read ↗

Predicting the insurgence of human genetic diseases associated to single point protein mutations with support vector machines and evolutionary information.Semantic proximity Read ↗

Deleterious SNP prediction: be mindful of your training data!Semantic proximity Read ↗

Approaches and resources for prediction of the effects of non-synonymous single nucleotide polymorphism on protein function and interactions.Semantic proximity Read ↗

Prediction of deleterious human alleles.Semantic proximity Read ↗

Prediction and interpretation of deleterious coding variants in terms of protein structural stabilitySemantic proximity Read ↗

Identification of deleterious mutations within three human genomes.Semantic proximity Read ↗

Predicting the effects of amino acid substitutions on protein function.Semantic proximity Read ↗

Prediction and interpretation of deleterious coding variants in terms of protein structural stability.Semantic proximity Read ↗

Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines.Semantic proximity Read ↗

Prediction of deleterious nonsynonymous single-nucleotide polymorphism for human diseases.Semantic proximity Read ↗

Sequence-based prediction of pathological mutations.Semantic proximity Read ↗

Decoding molecular mechanisms for loss-of-function variants in the human proteomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.