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Article

Predicting the phenotypic effects of non-synonymous single nucleotide polymorphisms based on support vector machines.

BMC bioinformatics - 16 Nov 2007

Tian Jian, Wu Ningfeng, Guo Xuexia, Guo Jun, Zhang Juhua, Fan Yunliu

Abstract excerpt

BACKGROUND: Human genetic variations primarily result from single nucleotide polymorphisms (SNPs) that occur approximately every 1000 bases in the overall human population. The non-synonymous SNPs (nsSNPs) that lead to amino acid changes in the protein product may account for nearly half of the known genetic variations linked to inherited human diseases. One of the key problems of medical genetics today is to...

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PMID: 18005451
DOI: 10.1186/1471-2105-8-450
PMCID: PMC2216041

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