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Article

Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course.

Journal of psychiatric research - 1 Feb 2013

Miller Shefali, Hallmayer Joachim, Wang Po W, Hill Shelley J, Johnson Sheri L, Ketter Terence A

Abstract excerpt

BACKGROUND: Gene-environment interactions may contribute to bipolar disorder (BD) clinical course variability. We examined effects of brain-derived neurotrophic factor (BDNF) val66met genotype and early life stress (ELS) upon illness severity and chronicity in adult BD patients. METHODS: 80 patients (43 BD I, 33 BD II, 4 BD not otherwise specified, mean ± SD age 46.4 ± 14.0 years, 63.7% female) receiving open...

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Identifiers

PMID: 23182421
DOI: 10.1016/j.jpsychires.2012.10.015
PMCID: PMC3529984

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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