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Article

Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma.

Journal of psychiatric research - 1 Jul 2013

Enoch Mary-Anne, Hodgkinson Colin A, Gorodetsky Elena, Goldman David, Roy Alec

Abstract excerpt

The serotonin transporter, encoded by the SLC6A4 gene, influences the synaptic actions of serotonin and is responsive to stress hormones. We hypothesized that 5-HTTLPR, a functional SLC6A4 promoter polymorphism, and two tightly-linked, putatively functional 3' UTR SNPs (rs3813034, rs1042173) might have independent effects on suicidal behavior in the context of childhood trauma (CT). DNA and Childhood Trauma...

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Identifiers

PMID: 23558235
DOI: 10.1016/j.jpsychires.2013.03.007
PMCID: PMC3646970

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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