Article
Association of MICA-129 polymorphism and circulating soluble MICA level with rheumatoid arthritis in a south Indian Tamil population.
International journal of rheumatic diseases - 1 Mar 2018
Mariaselvam Christina M, Boukouaci Wahid, Charron Dominique, Krishnamoorthy Rajagopal, Tamouza Ryad, Misra Durga P, Negi Vir S
Abstract excerpt
INTRODUCTION: Rheumatoid arthritis (RA) is a clinically heterogeneous chronic inflammatory disorder characterized by synovitis leading to joint destruction. Both genetic and environmental factors are involved in the pathogenesis of RA. Significant dysregulation of NKG2D, an activating receptor of natural killer and certain autoreactive T cells as well as its ligand major histocompatibility complex class I...
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