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Article

Functional MICA Variants Are Differentially Associated with Immune-Mediated Inflammatory Diseases.

International journal of molecular sciences - 6 Mar 2024

Wang Chin-Man, Tan Keng-Poo, Wu Yeong-Jian Jan, Zheng Jian-Wen, Wu Jianming, Chen Ji-Yih

Abstract excerpt

As the principal ligand for NKG2D, MICA elicits the recruitment of subsets of T cells and NK cells in innate immunity. MICA gene variants greatly impact the functionality and expression of MICA in humans. The current study evaluated whether MICA polymorphisms distinctively influence the pathogenesis of psoriasis (PSO), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) in Taiwanese subjects. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38474281
DOI: 10.3390/ijms25053036
PMCID: PMC10931785

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