Article
Micro RNA-146a But Not IRAK1 is Associated with Rheumatoid Arthritis in the Tunisian Population.
Genetic testing and molecular biomarkers - 1 Feb 2017
Hassine Hana Ben, Boumiza Asma, Sghiri Rim, Baccouche Khadija, Boussaid Imen, Atig Ahlem, Shakoor Zahid, Bouajina Elyes, Zemni Ramzi
Abstract excerpt
BACKGROUND: Rheumatoid arthritis (RA) is characterized by the production of an array of proinflammatory cytokines through the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway. Interleukin-1 receptor (IL-1R) and Toll-like receptors contain a common cytoplasmic motif the Toll/IL-1R (TIR) homology domain. This motif is required for NF-κB activation. IL-1R-associated kinase 1...
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