Article
Polymorphism of IL10, IL4, CTLA4, and DAO Genes in Cross-Reactive Nonsteroidal Anti-inflammatory Drug Hypersensitivity.
Journal of clinical pharmacology - 1 Jan 2018
Ferreira Vasconcelos Luciana Mabel, Rodrigues Raphael de Oliveira, Albuquerque Andressa Almeida, Barroso Gabrielle Dantheias, Sasahara Greyce Luri, Severo Ferreira Janaira Fernandes, Francelino Eudiana Vale, Cardoso Cynthia Chester, Barem Rabenhorst Silvia Helena, de Almeida Thereza Lúcia Prata, Nagao-Dias Aparecida Tiemi
Abstract excerpt
Our aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (-1082 G>A), IL4 (-589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction...
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