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Polymorphisms in Human IL4, IL10, and TNF Genes Are Associated with an Increased Risk of Developing NSAID-Exacerbated Respiratory Disease.

Genes - 28 Mar 2022

Reigada-Rivera María Luisa, Lozano Catalina Sanz, Rodilla Esther Moreno, García-Sánchez Asunción, García-Solaesa Virginia, Toledano Félix Lorente, González Ignacio Dávila, Isidoro-García María

Abstract excerpt

BACKGROUND: The role of genetics in non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (NERD) is unclear, with different candidates involved, such as HLA genes, genes related to leukotriene synthesis, and cytokine genes. This study aimed to determine possible associations between 22 polymorphisms in 13 cytokine genes. METHODS: We included 195 patients (85 with NERD and 110 with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35456412
DOI: 10.3390/genes13040605
PMCID: PMC9031626

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