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Article

Genetic and nongenetic factors that may predispose individuals to allergic drug reactions.

Current opinion in allergy and clinical immunology - 1 Aug 2018

Gibson Andrew, Ogese Monday, Pirmohamed Munir

Abstract excerpt

PURPOSE OF REVIEW: Defining predisposition to allergic drug reactions has largely focussed on HLA associations, but other genetic and nongenetic factors are also likely to be involved. RECENT FINDINGS: Polymorphic genetic variants in cytokine genes, including IL-10, and co-signalling pathways, including CTLA4, have been associated with allergic drug reactions, but the effect size is lower than with HLA alleles...

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Share to CTLA-4 Antigen
Share to Drug Hypersensitivity
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to HLA-B Antigens

Share to Interleukin-10

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Share to T-Lymphocytes

Source

Identifiers

PMID: 29889140
DOI: 10.1097/ACI.0000000000000459

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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