Article
Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy.
BMC cancer - 26 Jul 2017
Ludovini Vienna, Antognelli Cinzia, Rulli Antonio, Foglietta Jennifer, Pistola Lorenza, Eliana Rulli, Floriani Irene, Nocentini Giuseppe, Tofanetti Francesca Romana, Piattoni Simonetta, Minenza Elisa, Talesa Vincenzo Nicola, Sidoni Angelo, Tonato Maurizio, Crinò Lucio, Gori Stefania
Abstract excerpt
BACKGROUND: We investigated whether GSTT1 ("null" allele), GSTM1 ("null"allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast cancer (EBC) treated with adjuvant chemotherapy (CT). METHODS: This prospective trial included patients with stage I-III BC subjected to CT with CMF or FEC regimens. PCR-RFLP was performed for...
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