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Article

Polymorphisms of GSTP1 is associated with differences of chemotherapy response and toxicity in breast cancer.

Chinese medical journal - 1 Jan 2011

Zhang Bai-Lin, Sun Tong, Zhang Bao-Ning, Zheng Shan, Lü Ning, Xu Bing-He, Wang Xiang, Chen Guo-Ji, Yu Dian-Ke, Lin Dong-Xin

Abstract excerpt

BACKGROUND: Although chemotherapy is one of the most important treatments of breast cancer, it is limited by significant inter-individual variations in response and toxicity. The metabolism of epirubicin (EPI) and cyclophosphamide (CTX) is mainly mediated by cytochrome P450s (CYPs) and glutathione S-transferases (GSTs). It has been well-known that the activities of these enzymes are polymorphic in population due...

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Source

Identifiers

PMID: 21362365

Genes

GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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