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Article

Genetic polymorphisms and response to 5-fluorouracil, doxorubicin and cyclophosphamide chemotherapy in breast cancer patients.

Oncotarget - 11 Oct 2016

Tecza Karolina, Pamula-Pilat Jolanta, Lanuszewska Joanna, Grzybowska Ewa

Abstract excerpt

Clinical resistance to chemotherapy is one of the major problems in breast cancer treatment. In this study we analyzed possible impact of 22 polymorphic variants on the treatment response in 324 breast cancer patients. Selected genes were involved in FAC chemotherapy drugs transport (ABCB1, ABCC2, ABCG2, SLC22A16), metabolism (CYP1B1, CYP2C19, GSTT1, GSTM1, GSTP1, TYMS, MTHFR, DPYD), drug-induced damage repair...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multidrug Resistance-Associated Protein 2

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Source

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Identifiers

PMID: 27527855
DOI: 10.18632/oncotarget.11053
PMCID: PMC5341838

Genes

ABCB1
ABCC2
ERCC2
ABCG2
ATM
DPYD
ERCC1
GSTM1
GSTP1
GSTT1
MTHFR
TYMS
XRCC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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