Article
Effect of GSTP1 and ABCC4 gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-5-fluorouracil-based chemotherapy in Bangladeshi breast cancer patients.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 Jul 2015
Islam Md Siddiqul, Islam Mohammad Safiqul, Parvin Salma, Ahmed Maizbah Uddin, Bin Sayeed Muhammad Shahdaat, Uddin Mir Muhammad Nasir, Hussain Syed Md Akram, Hasnat Abul
Abstract excerpt
The most important cytotoxic drug namely, cyclophosphamide used in breast cancer along with epirubicin and 5-fluorouracil, is transported by ABCC transporters and detoxified by glutathione S-transferases (GSTs). The activities of these enzymes and transporters may vary in different population due to the presence of genetic polymorphisms. This study was aimed to evaluate the effects of GSTP1rs1695 and...
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