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Article

Relationship of MTHFR and NQO1 Pharmacogenetics and Chemotherapy Clinical Outcomes in Breast Cancer Patients.

Biochemical genetics - 1 Aug 2015

Chaturvedi Pankaj, Tulsyan Sonam, Agarwal Gaurav, Lal Punita, Agrawal Sushma, Mittal Rama D, Mittal Balraj

Abstract excerpt

The study aimed at evaluating the influence of MTHFR 677C>T and NQO1 609C>T polymorphisms in toxicity and response to chemotherapy in breast cancer patients. These two genes are involved in the folate homeostasis and bioactivation of chemotherapeutic drugs, respectively. In this study, 243 patients treated with FEC/FAC/methotrexate chemotherapy regimen were recruited and followed up for toxicity (NCI-CTCAE ver....

Read the complete abstract on PubMed

Topics

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methotrexate

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to NAD(P)H Dehydrogenase (Quinone)

Share to Neoplasm Staging

Share to Polymorphism, Single Nucleotide

Share to Treatment Outcome

Source

Identifiers

PMID: 26014925
DOI: 10.1007/s10528-015-9683-z

Genes

NQO1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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