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Article

Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations.

Pharmacogenomics - 1 Aug 2017

Gautier-Veyret Elodie, Bailly Sebastien, Fonrose Xavier, Tonini Julia, Chevalier Simon, Thiebaut-Bertrand Anne, Stanke-Labesque Françoise

Abstract excerpt

How pharmacogenetics modulates the inhibitory effects of inflammation on voriconazole trough concentration (Cmin) remains unknown. In 29 recipients of allogeneic hematopoietic stem cell transplantation retrospectively studied, both a genetic score (which aggregated CYP2C19 and CYP3A genotypes) and inflammation significantly influenced voriconazole Cmin (n = 260). A trend toward (p = 0.03) a greater impact of...

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Source

Identifiers

PMID: 28745547
DOI: 10.2217/pgs-2017-0054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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