Article
Effects of cytochrome P450 3A4 and non-genetic factors on initial voriconazole serum trough concentrations in hematological patients with different cytochrome P450 2C19 genotypes.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Dec 2017
Shao Beibei, Ma Yongcheng, Li Qiaoyan, Wang Yimeng, Zhu Zunmin, Zhao Hongwei, Sun Jun, Dong Lingfang, Zhu Yingli, Zhao Ningmin, Qin Yuhua
Abstract excerpt
1. Polymorphisms of cytochrome P450 2C19 (CYP2C19) is an important factor contributing to variability of voriconazole pharmacokinetics. Polymorphisms of CYP3A4, CYP3A5, CYP2C9 and non-genetic factors such as age, gender, body mass index (BMI), transaminase levels, concomitant medications might also affect voriconazole initial steady serum trough concentration (VICmin) in haematological patients, but the effects...
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