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Article

The influence of CYP2C19 polymorphisms on voriconazole trough concentrations: Systematic review and meta-analysis.

Mycoses - 1 Aug 2021

Zhang Ying, Hou Kelu, Liu Fang, Luo Xingxian, He Shiyu, Hu Lei, Yang Changqing, Huang Lin, Feng Yufei

Abstract excerpt

BACKGROUND: Voriconazole primary metabolism is catalysed by CYP2C19. A large variability of trough concentrations in patients with invasive fungal infection treated with voriconazole has been observed in clinical practice. It remains controversial whether the CYP2C19 polymorphisms are responsible for voriconazole metabolism in the individual variation. OBJECTIVES: The primary aim of this study was to assess the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33896064
DOI: 10.1111/myc.13293

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