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Article

Combined impact of hypoalbuminemia and pharmacogenomic variants on voriconazole trough concentration: data from a real-life clinical setting in the Chinese population.

Journal of chemotherapy (Florence, Italy) - 1 May 2024

Li Yuanyuan, Zhang Ying, Zhao Jinxia, Bian Jialu, Zhao Yinyu, Hao Xu, Liu Boyu, Hu Lei, Liu Fang, Yang Changqing, Feng Yufei, Huang Lin

Abstract excerpt

Voriconazole (VRC) displays highly variable pharmacokinetics impacting treatment efficacy and safety. To provide evidence for optimizing VRC therapy regimens, the authors set out to determine the factors impacting VRC steady-state trough concentration (Cmin) in patients with various albumin (Alb) level. A total of 275 blood samples of 120 patients and their clinical characteristics and genotypes of CYP2C19,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37599449
DOI: 10.1080/1120009X.2023.2247208

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