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Article

Inflammation altered correlation between CYP2C19 genotype and CYP2C19 activity in patients receiving voriconazole.

Clinical and translational science - 1 Jul 2024

Klomp Sylvia D, Veringa Anette, Alffenaar Jan-Willem C, de Boer Mark G J, Span Lambert F R, Guchelaar Henk-Jan, Swen Jesse J

Abstract excerpt

Voriconazole is the cornerstone of the treatment and prevention of fungal infections. While there is a good correlation between CYP2C19 genotype and voriconazole exposure during prophylactic treatment, no correlation was found in patients with invasive aspergillosis. Proinflammatory cytokines result in inhibition of CYP2C19 enzyme activity (and may result in phenoconversion). Here we investigated the relationship...

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Identifiers

PMID: 39010708
DOI: 10.1111/cts.13887
PMCID: PMC11250525

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