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Article

Effects of CYP3A4 polymorphisms on the plasma concentration of voriconazole.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Apr 2015

He H-R, Sun J-Y, Ren X-D, Wang T-T, Zhai Y-J, Chen S-Y, Dong Y-L, Lu J

Abstract excerpt

Voriconazole is frequently utilized for the prevention and treatment of invasive fungal infections (IFIs), and is extensively metabolized by the cytochrome P450 (CYP) system. The impact of activity of the genes encoding CYP3A4, CYP3A5, and CYP2C9 on the pharmacokinetics of voriconazole cannot be ignored because, second to CYP2C19, they are the most important enzymes involved in voriconazole metabolism. The...

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Identifiers

PMID: 25515945
DOI: 10.1007/s10096-014-2294-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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