Pharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients-A Prospective Study From North India.

Abstract excerpt

Voriconazole has variable pharmacokinetics, significant interactions, and a narrow therapeutic window, requiring drug monitoring. This study evaluated CYP2C19 genotype and voriconazole levels in North Indian children, a population with limited pharmacogenomic data. It is a prospective single-center study (August 2023-January 2025) in children with leukemia/HSCT. Voriconazole levels were measured using the ARK...

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