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Article

Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.

Nature communications - 26 Jul 2017

Kucinski Iwo, Dinan Michael, Kolahgar Golnar, Piddini Eugenia

Abstract excerpt

Cell competition is a form of cell interaction that causes the elimination of less fit cells, or losers, by wild-type (WT) cells, influencing overall tissue health. Several mutations can cause cells to become losers; however, it is not known how. Here we show that Drosophila wing disc cells carrying functionally unrelated loser mutations (Minute and mahjong) display the common activation of multiple stress...

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Source

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Identifiers

PMID: 28743877
DOI: 10.1038/s41467-017-00145-y
PMCID: PMC5526992

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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