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Article

An ancient defense system eliminates unfit cells from developing tissues during cell competition.

Science (New York, N.Y.) - 5 Dec 2014

Meyer S N, Amoyel M, Bergantiños C, de la Cova C, Schertel C, Basler K, Johnston L A

Abstract excerpt

Developing tissues that contain mutant or compromised cells present risks to animal health. Accordingly, the appearance of a population of suboptimal cells in a tissue elicits cellular interactions that prevent their contribution to the adult. Here we report that this quality control process, cell competition, uses specific components of the evolutionarily ancient and conserved innate immune system to eliminate...

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Identifiers

PMID: 25477468
DOI: 10.1126/science.1258236
PMCID: PMC5095928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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