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Article

Familial colorectal cancer: search for novel predisposition genes.

Human genomics - 30 Dec 2025

Försti Asta, Miao Beiping, Kumar Abhishek, Dymerska Zaremba Dagmara, Marciniak Magdalena, Lubinski Jan, Hemminki Kari

Abstract excerpt

BACKGROUND: Family history of colorectal cancer (CRC) and multiple primary CRCs in a single person may indicate inherited CRC predisposition. METHODS: In the present study, we performed whole exome/genome sequencing on germline DNA from at least two CRC cases in 19 families and from family members with a double primary CRC from seven additional families. We used a set of in silico predictions in combination with...

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Source

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Identifiers

PMID: 41469725
DOI: 10.1186/s40246-025-00901-y
PMCID: PMC12849417

Genes

APCDD1
CYBA
PTK7
SRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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