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BRIP1, a Gene Potentially Implicated in Familial Colorectal Cancer Type X.

Cancer prevention research (Philadelphia, Pa.) - 1 Feb 2021

Martín-Morales Lorena, Garre Pilar, Lorca Víctor, Cazorla Marta, Llovet Patricia, Bando Inmaculada, García-Barberan Vanesa, González-Morales María Luisa, Esteban-Jurado Clara, de la Hoya Miguel, Castellví-Bel Sergi, Caldés Trinidad

Abstract excerpt

Familial colorectal cancer Type X (FCCTX) comprises a heterogeneous group of families with an increased risk of developing colorectal cancer and other related tumors, but with mismatch repair-proficient, microsatellite-stable (MSS) tumors. Unfortunately, the genetic basis underlying their cancer predisposition remains unknown. Although pathogenic germline variants in BRIP1 increase the risk of developing...

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PMID: 33115781
DOI: 10.1158/1940-6207.CAPR-20-0316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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