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Article

Modulation of rob expression accelerates development of antibiotic resistance in Yersinia enterocolitica.

Nucleic acids research - 24 Aug 2026

Wang Xinyu, Chen Taichi, Jonker Martijs, de Koster Alphonse, de Leeuw Wim, Ter Kuile Benno H, Dugar Gaurav

Abstract excerpt

Multidrug-resistant bacteria pose a severe threat to global health. Mutations in transcriptional regulators accelerate the emergence of multidrug resistance and may have a crucial impact on pathogen evolvability under antibiotic exposure. Here, we investigate these dynamics in the bacterial pathogen Yersinia enterocolitica. In this organism, we identified a high-frequency de novo mutation in the promoter of an...

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Share to Anti-Bacterial Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Drug Resistance, Multiple, Bacterial

Share to Gene Expression Regulation, Bacterial

Share to Promoter Regions, Genetic

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Identifiers

PMID: 42639795
DOI: 10.1093/nar/gkag643
PMCID: PMC13504276

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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