Article
Genetic variation in the gene LRP2 increases relapse risk in multiple sclerosis.
Journal of neurology, neurosurgery, and psychiatry - 1 Oct 2017
Zhou Yuan, Graves Jennifer S, Simpson Steve, Charlesworth Jac C, Mei Ingrid van der, Waubant Emmanuelle, Barcellos Lisa F, Belman Anita, Krupp Lauren, Lucas Robyn, Ponsonby Anne-Louise, Taylor Bruce V
Abstract excerpt
BACKGROUND: Due to the lack of prospective studies with longitudinal data on relapse, past genetic studies have not attempted to identify genetic factors that predict relapse risk (the primary endpoint of many pivotal clinical trials testing the efficacy of multiple sclerosis (MS) disease-modifying drugs) at a genome-wide scale. METHODS: We conducted a genome-wide association analysis (GWAS) to identify genetic...
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