Article
Variation within MBP gene predicts disease course in multiple sclerosis.
Brain and behavior - 1 Apr 2017
Zhou Yuan, Simpson Steve, Charlesworth Jac C, van der Mei Ingrid, Lucas Robyn M, Ponsonby Anne-Louise, Taylor Bruce V
Abstract excerpt
OBJECTIVE: Prognosis following a first demyelinating event is difficult to predict, with no genetic markers of MS progression currently identified. Myelin basic protein (MBP) is a major component of the myelin sheath of CNS neurons and may play a central role in demyelinating diseases such as MS. However, genetic variation in MBP has not been implicated in MS onset risk in large genome-wide association studies....
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