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Article

A novel protein kinase is essential in bloodstream Trypanosoma brucei.

International journal for parasitology - 1 Jul 2016

Jensen Bryan C, Booster Nick, Vidadala Rama Subba Rao, Maly Dustin J, Parsons Marilyn

Abstract excerpt

Human African trypanosomiasis a fatal disease for which no vaccines exist and treatment regimens are difficult. Here, we evaluate a Trypanosoma brucei protein kinase, AEK1, as a potential drug target. Conditional knockouts confirmed AEK1 essentiality in bloodstream forms. For chemical validation, we overcame the lack of AEK1 inhibitors by creating parasites expressing a single, functional analog-sensitive AEK1...

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Source

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Identifiers

PMID: 27018127
DOI: 10.1016/j.ijpara.2016.03.001
PMCID: PMC4925258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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