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Article

A Mitogen-activated protein kinase controls differentiation of bloodstream forms of Trypanosoma brucei.

Eukaryotic cell - 1 Jul 2006

Domenicali Pfister Debora, Burkard Gabriela, Morand Sabine, Renggli Christina Kunz, Roditi Isabel, Vassella Erik

Abstract excerpt

African trypanosomes undergo differentiation in order to adapt to the mammalian host and the tsetse fly vector. To characterize the role of a mitogen-activated protein (MAP) kinase homologue, TbMAPK5, in the differentiation of Trypanosoma brucei, we constructed a knockout in procyclic (insect) forms from a differentiation-competent (pleomorphic) stock. Two independent knockout clones proliferated normally in...

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Identifiers

PMID: 16835456
DOI: 10.1128/EC.00094-06
PMCID: PMC1489280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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