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Article

High‐Throughput Analysis of an RNAi Library Identifies Novel Kinase Targets in Trypanosoma brucei

11 Jun 2011

Abstract excerpt

New drugs are needed to treat human African trypanosomiasis because the currently approved treatments are toxic or limited in efficacy. One strategy for developing new drugs involves discovering novel genes whose products can be targeted for modulation by small-molecule chemotherapeutic agents. The Trypanosoma brucei genome contains many genes with the potential to become such targets. Kinases represent one group...

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PMID: 21668652
DOI: 10.1111/j.1747-0285.2011.01156.x

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