Article
P53 deregulation in Epstein-Barr virus-associated gastric cancer.
Cancer letters - 28 Sept 2017
Ribeiro Joana, Malta Mariana, Galaghar Ana, Silva Fernanda, Afonso Luís Pedro, Medeiros Rui, Sousa Hugo
Abstract excerpt
TP53 is a tumour suppressor gene frequently mutated in human cancers; nevertheless, in EBV-associated malignancies mutations are uncommon despite frequent deregulation of the p53 pathway. In this study, we aimed to investigate p53 expression, TP53 mRNA levels and TP53 mutations in EBV-associated gastric carcinoma (EBVaGC). A case-control study was performed using 46 patients: 15 EBVaGC and 31 EBV-negative GC...
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