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Epstein-Barr Virus MicroRNA miR-BART5-3p Inhibits p53 Expression

11 Sept 2018

Abstract excerpt

EBV encodes 44 mature microRNAs, which have been proven to promote EBV-associated diseases by targeting host genes and self-viral genes. In EBV-associated carcinomas, the expression of viral protein is limited but the expression of BART microRNAs is extremely high, suggesting that they could be major factors in the contribution of EBV-associated tumorigenesis. p53 is a critical tumor suppressor. Unlike in most...

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PMID: 30209170
DOI: 10.1128/jvi.01022-18

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