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Article

A clinicopathologic study of diencephalic pediatric low-grade gliomas with BRAF V600 mutation.

Acta neuropathologica - 1 Oct 2015

Ho Cheng-Ying, Mobley Bret C, Gordish-Dressman Heather, VandenBussche Christopher J, Mason Gary E, Bornhorst Miriam, Esbenshade Adam J, Tehrani Mahtab, Orr Brent A, LaFrance Delecia R, Devaney Joseph M, Meltzer Beatrix W, Hofherr Sean E, Burger Peter C, Packer Roger J, Rodriguez Fausto J

Abstract excerpt

Among brain tumors, the BRAF (V600E) mutation is frequently associated with pleomorphic xanthoastrocytomas (PXAs) and gangliogliomas (GGs). This oncogenic mutation is also detected in ~5 % of other pediatric low-grade gliomas (LGGs) including pilocytic astrocytomas (PAs) and diffuse astrocytomas. In the current multi-institutional study of 56 non-PXA/non-GG diencephalic pediatric LGGs, the BRAF (V600) mutation...

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PMID: 26264609
DOI: 10.1007/s00401-015-1467-3

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BRAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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